Wetenschappelijk onderzoek

In de eeuwenoude Ayurvedische en Chinese geneeskunde wordt de heilzame werking van kurkuma onderkend. Naar deze werking wordt veel onderzoek gedaan.

In de opsomming hieronder staan links naar publicaties over een aantal van deze onderzoeken, gegroepeerd naar lichaamsfunctie. De volledige titels van deze artikelen zijn onderaan deze pagina opgesomd met corresponderende EFSA-ID-nummers.

 

Botten en gewrichten

Botopbouw /beenderstelsel (EFSA ID 4012)

Behoud van sterke botten (EFSA ID 4012)

Behoud van soepele gewrichten (EFSA-ID 3748 en 4014)

 

Hart en bloedcirculatie

Hart en bloedvaten ondersteunend (EFSA ID 4010)

Gunstig effect op bloedsomloop (EFSA ID 4010)

 

Huid-regenererend

Bescherming tegen huidveroudering (EFSA ID 4008)

 

Luchtwegen

Positief effect op luchtwegen (EFSA ID 4010)

Verzachtende invloed op luchtwegen (EFSA ID 4010)

Tegen hooikoorts (PubMed)

 

Spijsvertering en lever

Ondersteunt spijsvertering (EFSA ID 2252)

Ondersteunt de werking van de lever (EFSA ID 4013)

Reinigen van het lichaam (EFSA ID 4013)

Helpt eetlust verminderen (EFSA ID 2744)

Vermindert vetopslag (EFSA ID 2751)

 

Weerstand/afweer/immuunsysteem

Ondersteunt de lichaamsafweer (EFSA ID 4009)

Stimuleert immuunsysteem (EFSA ID 4009)

Verhoogt de weerstand van organisme (EFSA ID 4009)

 

 

 

Links naar artikelen (op onder meer PubMed):

 

Antioxidant activities of curcumin in allergic rhinitis


Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse

 

Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases

 

Curcumin: A Review for Health Benefits

 

Curcumin: A Review of Its’ Effects on Human Health

 

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review
 

Role of curcumin in systemic and oral health: An overview
 

Neuroprotective effects of Curcumin

 
The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

 
Curcumin and Cancer Stem Cells: Curcumin Has Asymmetrical Effects on Cancer and Normal Stem Cells

 
Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people

 

  

Klik hier voor een (Engelstalige) publicatie-overzicht over wetenschappelijk onderzoek naar kurkuma en curcumine.

 

onderzoek edit.jpg

 

Volledige titels van de publicaties over wetenschappelijk onderzoek naar kurkuma en curcumine:

 

 

EFSA ID 2252

Kowluru RA and Kanwar M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metab (Lond), Jan 2007; 4: 8.

Kumar V, Lewis SA, Mutalik S, Shenoy DB, Venkatesh, and Udupa N. Biodegradable microspheres of curcumin for treatmet

 

EFSA 2744

Ammon HP and Wahl MA, 1991. Pharmacology of Curcuma longa. Planta Med, 57, 1-7.

Araujo CC and Leon LL, 2001. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz, 96, 723-728.

Blumenthal M, Goldberg A, Brinckmann J, 2000. Herbal Medicine: Expanded Commission E Monographs. American Botanical Council, Austin, TX.

Bruneton J, 1999. Pharmacognosie Phytochimie plantes médicinales. Tec & Doc, Lavoisier, Paris.

Cahiers de l'Agence, 1998. Les Cahiers de l’Agence n°3. Médicaments à base de plantes. République Française, Ministère de l'Emploi et de la Solidarité, Paris.

Gautam SC, Gao X, Dulchavsky S, 2007. Immunomodulation by curcumin. Adv Exp Med Biol, 595, 321-341.

Grant KL and Schneider CD, 2000. Turmeric. Am J Health Syst Pharm, 57, 1121-1122.

Gruenwald J, Brendler T, Jaenicke C, 2004. PDR for herbal medicines. Thomson Reuters, Montvale.

Rombi M, Robert D, Guedon D, Rosier-Sala C, Renzacci E, 2007. 120 plantes médicinales : Composition, mode d'action et intérêt thérapeutique ... de l'Ail à la Vigne rouge. Alpen Editions Monaco.

Roux D and Danielle R, 2005. Les nouvelles plantes qui soignent: découvrez les pouvoirs naturels des plantes médicinales. Alpen Editions, Monaco.

Shishodia S, Singh T, Chaturvedi MM, 2007. Modulation of transcription factors by curcumin. Adv Exp Med Biol, 595, 127-148.

Tirkey N, Kaur G, Vij G, Chopra K, 2005. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol, 5, 15. 

 

EFSA 2751

Asai A, Nakagawa K, Miyazawa T, 1999. Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice. Biosci Biotechnol Biochem, 63, 2118-2122.

Asai A and Miyazawa T, 2001. Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr, 131, 2932-2935.

Deshpande UR, Joseph LJ, Manjure SS, Samuel AM, Pillai D, Bhide SV, 1997. Effects of turmeric extract on lipid profile in human subjects. Medical Science Research, 25, 695-698.

Gogte VVM, 2000. Ayurvedic Pharmacology and Therapeutic Uses of Medicinal Plants. Bharatiya Vidya Bhavan, Mumbai.

Kapoor LD, 1990. Handbook of Ayurvedic Medicinal Plants. CRC Press, Boca Raton.

Pole S, 2006. Ayurvedic Medicine: The Principles of Traditional Practice. Churchill Livingstone, London, Edinburgh.

Rukkumani R, Aruna K, Varma PS, Rajasekaran KN, Menon VP, 2005. Comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles. J Med Food, 8, 256-260.

Sharma PC, Yelne MB, Dennis TJ, 2000. Database on Medical Plants used in Ayurveda. Central Council for Research in Ayurveda & Siddha, New Dehli.

WHO (World Health Organization), 1999. WHO Monographs on Selected Medicinal Plants. WHO (World Health Organization), Geneva.

Williamson EM, 2002. Major Herbs of Ayurveda. Churchill Livingstone, London, Edinburgh.

 

EFSA 3748

Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM, 2005. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evidence-based Complementary and Alternative Medicine, 2, 301-308.

Arora RB, Kapoor V, Basu N, Jain AP, 1971. Anti-inflammatory studies on Curcuma longa (turmeric). Indian J Med Res, 59, 1289-1295.

Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, Stafford G, Chen G, Lantz RC, Jolad SD, Solyom AM, Kiela PR, Timmermann BN, 2006. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum, 54, 3452-3464.

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P, 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64, 353-356.

Srivastava KC, 1989. Extracts from two frequently consumed spices--cumin (Cuminum cyminum) and turmeric (Curcuma longa)--inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. Prostaglandins Leukot Essent Fatty Acids, 37, 57-64.

 

EFSA ID 3908

ESCOP, German Commission E, WHO monograph

 

EFSA ID 4007

Aggarwal BB, Kumar A, Bharti AC, 2003. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res, 23, 363-398.

Aggarwal BB Aggarwal BB, Shishodia S, Surh YJ, 2007. The molecular targets and therapeutic uses of curcumin in health and disease. Springer, New York.

Bonte F, Noel-Hudson MS, Wepierre J, Meybeck A, 1997. Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress. Planta Med, 63, 265-266.

Chainani-Wu N, 2003. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). The Journal of Alternative & Complementary Medicine, 9, 161-168.

Devi L, 1998. Comment on: Ana Ramirez-Boscá, Alfonso Soler, Miguel Angel Carrión Gutierrez, Juan Laborda Alvarez and Eliseo Quintanilla Almagro "Antioxidant curcuma extracts decrease the blood lipid peroxide levels of human subjects" AGE Volume 18, Number 4 / October, 1995 pp 167-169. American Botanical Council-HerbClip.

Durgaprasad S, Pai CG, Vasanthkumar, Alvres JF, Namitha S, 2005. A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. Indian J Med Res, 122, 315-318.

Grant K, 2000. Turmeric. Am J Health-Syst Pharm, 57, 1121-1122.

Gruenwald J, Brendler T, Jaenicke C, 2004. PDR for Herbal medicines. Thomson PDR, Montvale, NJ.

Joe B, Vijaykumar M, Lokesh BR, 2004. Biological properties of curcumin-cellular and molecular mechanisms of action. Critical reviews in food science and nutrition, 44, 97-111.

Kerr C, 2002. Curry ingredient protects skin against radiation. Oncology, 3, 712.

Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P, Srimal RC, 1999. Efficacy of curcumin in the management of chronic anterior uveitis. Phytotherapy Research, 13, 318-22.

Masuda T, Isobe J, Jitoe A, Nakatani N, 1992. Antioxidative curcuminoids from rhizomes of Curcuma xanthorrhiza. Phytochemistry, 31, 3645-3647.

Masuda T, Jitoe A, Isobe J, Nakatani N, Yonemori S, 1993. Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica. Phytochemistry, 32, 1557-1557.

Menon VP and Sudheer AR, 2007. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol, 595, 105-125.

Mills S and Bone K, 2000. Turmeric (Curcuma L.). In: Principles and practice of phytotherapy. Modern herbal medicine. Churchill Livingstone, London, Edinburgh, 569-580.

Motterlini R, Foresti R, Bassi R, Green CJ, 2000. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radical Biology and Medicine, 28, 1303-1312.

Nicol M and Maudet M, 2005. Le Curcumin. Mèdicine et nutrition. Aliments, 41, 135-143.

Nutranews. Science Nutrition Prèvention et Santè, Le Curcuma, http://www.nutranews.org/article.php3?id_rubrique=24&id_article=510.

Ramirez-Bosca A, Soler A, Carrion MA, Laborda J, Quintanilla E, 1995. Antioxidant curcuma extracts decrease the blood lipid peroxide levels of human subjects. Age, 18, 167-169.

Ramsewak RS, DeWitt DL, Nair MG, 2000. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine, 7, 303-308.

Reddy AC and Lokesh BR, 1994. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food Chem Toxicol, 32, 279-283.

Reddy BS and Rao CV, 2004. Chemoprevention of Cancer by Curcumin. In: Cancer Chemoprevention, Vol. I Promisisng Cancer Chemoprevention Agents. Kelloff G, Hawk ET, Sigman CC (eds.). Humana Press, Totowa NJ, 169-175.

Ross IA, 2003. Curcuma longa L. In: Medicinal plants of the world. Chemical constituents, traditional and modern medicinal uses. Humana Press, Totowa, New Jersey.

Saikia AP, Ryakala VK, Sharma P, Goswami P, Bora U, 2006. Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics. J Ethnopharmacol, 106, 149-157.

Satoskar RR, Shah SJ, Shenoy SG, 1986. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol, 24, 651-654.

Selvam R, Subramanian L, Gayathri R, Angayarkanni N, 1995. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol, 47, 59-67.

Shalini VK and Srinivas L, 1987. Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa). Mol Cell Biochem, 77, 3-10.

Sharma OP, 1976. Antioxidant activity of curcumin and related compounds. Biochem Pharmacol, 25, 1811-1812.

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P, 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta medica, 64, 353-356.

Soni KB and Kuttan R, 1992. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol, 36, 273-275.

Sreejayan N and Rao MN, 1996. Free radical scavenging activity of curcuminoids. Arzneimittelforschung, 46, 169-171.

Sreejayan and Rao MN, 1997. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol, 49, 105-107.

Subramanian M, Sreejayan, Rao MN, Devasagayam TP, Singh BB, 1994. Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants. Mutat Res, 311, 249-255.

Toda S, Miyase T, Arichi H, Tanizawa H, Takino Y, 1985. Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chem Pharm Bull (Tokyo), 33, 1725-1728.

Wichtl M and Anton R, 1999. Curcumae longae rhizoma. In: Plantes thérapeutiques : tradition, pratique officinale, science et thérapeutique. Ed. Tec & Doc, Lavoisier, Paris, 151-154.

Zhao BL, Li XJ, He RG, Cheng SJ, Xin WJ, 1989. Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals. Cell Biophys, 14, 175-185.

 

EFSA ID 4008

Int J Low Extrem Wounds. 2003 Mar;2(1):25-39. Plant medicines of Indian origin for wound healing activity: a review. Biswas TK, Mukherjee B

Int J Low Extrem Wounds. 2005 Dec;4(4):205-13. Turmeric (Curcuma longa) rhizome paste and honey show similar wound healing potential: a preclinical study in rabbits. Kundu S, Biswas TK, Das P, Kumar S, De DK. 

J Invest Dermatol. 2007 Aug;127(8):1992-2000. Epub 2007 Apr 5. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. Dujic J, Kippenberger S, Hoffmann S, Ramirez-Bosca A, Miquel J, Diaz-Alperi J, Bereiter-Hahn J, Kaufmann R, Bernd A.

Planta Med. 1997 Jun;63(3):265-6. Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress. Bonté F, Noel-Hudson MS, Wepierre J, Meybeck A.

 

EFSA ID 4009

Adhvaryu MR, Reddy N, Parabia MH, 2007. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. World J Gastroenterol, 13, 3199-3205.

Balcerek M and Matlawska I, 2005. [Preventive role of curcumin in lung cancer]. Przegl Lek, 62, 1180-1181.

Bright JJ, 2007. Curcumin and autoimmune disease. Adv Exp Med Biol, 595, 425-451.

Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO, 2007. Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol, 100, 43-48.

Gautam SC, Gao X, Dulchavsky S, 2007. Immunomodulation by curcumin. Adv Exp Med Biol, 595, 321-341.

Gogte VVM, 2000. Ayurvedic Pharmacology and Therapeutic Uses of Medicinal Plants. Bharatiya Vidya Bhavan, Mumbai.

Indian Ministry of Health and Family Welfare, 2001. The Ayurvedic Pharmacopoeia of India. Government of India, Ministry of Health and Family Welfare, Department of Indian Systems of Medicine and Homeopathy, New Dehli, India.

Jagetia GC and Aggarwal BB, 2007. "Spicing up" of the immune system by curcumin. J Clin Immunol, 27, 19-35.

Kapoor LD, 1990. Handbook of Ayurvedic Medicinal Plants. CRC Press, Boca Raton.

Menon VP and Sudheer AR, 2007. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol, 595, 105-125.

Mohanty I, Singh Arya D, Dinda A, Joshi S, Talwar KK, Gupta SK, 2004. Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. Life Sci, 75, 1701-1711.

Pole S, 2006. Ayurvedic Medicine: The Principles of Traditional Practice. Churchill Livingstone, London, Edinburgh.

Rao CV, 2007. Regulation of COX and LOX by curcumin. Adv Exp Med Biol, 595, 213-226.

Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M, 2006. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev, 11, 128-150.

Tilak JC, Banerjee M, Mohan H, Devasagayam TP, 2004. Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother Res, 18, 798-804.

Wattanapitayakul SK, Chularojmontri L, Herunsalee A, Charuchongkolwongse S, Niumsakul S, Bauer JA, 2005. Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity. Basic Clin Pharmacol Toxicol, 96, 80-87.

WHO (World Health Organization), 2007. WHO Monographs on Selected Medicinal Plants. WHO (World Health Organization), Geneva.

Williamson EM, 2002. Major Herbs of Ayurveda. Churchill Livingstone, London, Edinburgh.

Yelne M, Sharma P, Dennis T, 2002. Database on Medicinal Plants Used in Ayurveda (Volume 4). Central Council for Research in Ayurveda & Siddha.

Youn HS, Saitoh SI, Miyake K, Hwang DH, 2006. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem Pharmacol, 72, 62-69.

Zafir A and Banu N, 2007. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. Eur J Pharmacol, 572, 23-31.

Zhou H, Wong YF, Cai X, Liu ZQ, Jiang ZH, Bian ZX, Xu HX, Liu L, 2006. Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. Biol Pharm Bull, 29, 253-260.

 

EFSA ID 4010

J Clin Immunol. 2007 Jan;27(1):19-35. Epub 2007 Jan 9. "Spicing up" of the immune system by curcumin. Jagetia GC, Aggarwal BB.

Adv Exp Med Biol. 2007;595:359-77. Cardioprotective effects of curcumin. Miriyala S, Panchatcharam M, Rengarajulu P.

J Med Food. 2005 Summer;8(2):256-60. Comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles. Rukkumani R, Aruna K, Varma PS, Rajasekaran KN, Menon VP.

Atherosclerosis. 1999 Dec;147(2):371-8. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Ramírez-Tortosa MC, Mesa MD, Aguilera MC, Quiles JL, Baró L, Ramirez-Tortosa CL, Martinez-Victoria E, Gil A

BMC Complement Altern Med. 2006 Feb 19;6:3. Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury. Mohanty I, Arya DS, Gupta SK.

Am J Chin Med. 2005;33(3):449-57. Effect of curcuma herbs on vasomotion and hemorheology in spontaneously hypertensive rat. Goto H, Sasaki Y, Fushimi H, Shibahara N, Shimada Y, Komatsu K.

Life Sci. 2005 Jul 8;77(8):837-57. Epub 2005 Apr 14. Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats.

Life Sci. 2004 Aug 20;75(14):1701-11. Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. Mohanty I, Singh Arya D, Dinda A, Joshi S, Talwar KK, Gupta SK.

Vascul Pharmacol. 2007 Jul;47(1):25-30. Epub 2007 Mar 27. The relaxant effect of curcumin on porcine coronary arterial ring segments. Xu PH, Long Y, Dai F, Liu ZL

Indian J Exp Biol. 2007 Mar;45(3):272-7. Curcuma longa as feed additive in broiler birds and its patho-physiological effects. Kumari P, Gupta MK, Ranjan R, Singh KK, Yadava R.

Bioresour Technol. 2006 Aug;97(12):1372-6. Epub 2005 Aug 19. Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Lee HS.

Basic Clin Pharmacol Toxicol. 2005 Jan;96(1):80-7. Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity. Wattanapitayakul SK, Chularojmontri L, Herunsalee A, Charuchongkolwongse S, Niumsakul S, Bauer JA. [no effect seen]

 

EFSA ID 4011

J Clin Immunol. 2007 Jan;27(1):19-35. Epub 2007 Jan 9. "Spicing up" of the immune system by curcumin. Jagetia GC, Aggarwal BB.

J Clin Rheumatol. 2004 Oct;10(5):236-245. A 32-Week Randomized, Placebo-Controlled Clinical Evaluation of RA-11, an Ayurvedic Drug, on Osteoarthritis of the Knees. Chopra A, Lavin P, Patwardhan B, Chitre D.

 

EFSA ID 4012

Chopra A, Lavin P, Patwardhan B, Chitre D, 2004. A 32-Week Randomized, Placebo-Controlled Clinical Evaluation of RA-11, an Ayurvedic Drug, on Osteoarthritis of the Knees. J Clin Rheumatol, 10, 236-245.

Jagetia GC and Aggarwal BB, 2007. "Spicing up" of the immune system by curcumin. J Clin Immunol, 27, 19-35.

Kapoor LD, 1990. Handbook of Ayurvedic Medicinal Plants. CRC Press, Boca Raton.

Pole S, 2006. Ayurvedic Medicine: The Principles of Traditional Practice. Churchill Livingstone, London, Edinburgh.

Williamson EM, 2002. Major Herbs of Ayurveda. Churchill Livingstone, London, Edinburgh.

Yelne M, Sharma P, Dennis T, 2002. Database on Medicinal Plants Used in Ayurveda (Volume 4). Central Council for Research in Ayurveda & Siddha.

 

EFSA ID 4013

World J Gastroenterol. 2007 Jun 21;13(23):3199-205. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. Adhvaryu MR, Reddy N, Parabia MH.

Mol Cell Biochem. 2006 Aug;288(1-2):115-23. Epub 2006 May 12. Curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver. Vanisree AJ, Sudha N.

Nutrition. 2003 Sep;19(9):800-4. Oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet. Mesa MD, Aguilera CM, Ramírez-Tortosa CL, Ramírez-Tortosa MC, Quiles JL, Baró L, Martínez de Victoria E, Gil A.

Nutr Cancer. 2003;45(1):53-9. Suppression of altered hepatic foci development by curcumin in wistar rats. Shukla Y, Arora A.

Biofactors. 1998;8(1-2):51-7. An ethanolic-aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits Quiles JL, Aguilera C, Mesa MD, Ramírez-Tortosa MC, Baró L, Gil A.

Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue. Padmaja S, Raju TN.

 

EFSA ID 4014

Evid Based Complement Alternat Med. 2007 Jun;4(2):181-190. Epub 2007 Apr 23. Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies Salvioli S, Sikora E, Cooper EL, Franceschi C.

J Clin Immunol. 2007 Jan;27(1):19-35. Epub 2007 Jan 9. "Spicing up" of the immune system by curcumin. Jagetia GC, Aggarwal BB.

Brain Res. 2007 Aug 8;1162:9-18. Epub 2007 Jun 21. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Xu Y, Ku B, Cui L, Li X, Barish PA, Foster TC, Ogle WO.

Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. Zafir A, Banu N.

Methods Find Exp Clin Pharmacol. 2007 Jan-Feb;29(1):19-25. Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity.

Eur J Pharmacol. 2007 Apr 30;561(1-3):54-62. Epub 2007 Jan 19. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. Jiang J, Wang W, Sun YJ, Hu M, Li F, Zhu DY

J Ethnopharmacol. 2007 Mar 21;110(2):356-63. Epub 2006 Oct 17. Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test. Xia X, Cheng G, Pan Y, Xia ZH, Kong LD.

Brain Res. 2006 Nov 29;1122(1):56-64. Epub 2006 Oct 3. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Xu Y, Ku B, Tie L, Yao H, Jiang W, Ma X, Li X.

Biol Pharm Bull. 2006 May;29(5):938-44. Ethanolic extracts from Curcuma longa attenuates behavioral, immune, and neuroendocrine alterations in a rat chronic mild stress model. Xia X, Pan Y, Zhang WY, Cheng G, Kong LD

Life Sci. 2006 Mar 13;78(16):1884-91. Epub 2005 Nov 2. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Sumanont Y, Murakami Y, Tohda M, Vajragupta O, Watanabe H, Matsumoto K.

Pharmacol Biochem Behav. 2005 Sep;82(1):200-6. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH, Li XJ.

Eur J Pharmacol. 2005 Jul 25;518(1):40-6. The effects of curcumin on depressive-like behaviors in mice. Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH, Li XJ.

Biol Pharm Bull. 2006 Feb;29(2):253-60. Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. Zhou H, Wong YF, Cai X, Liu ZQ, Jiang ZH, Bian ZX, Xu HX, Liu L.